SEROTONIN TOXICITY

Serotonin is a naturally produced substance in the body, essential for various functions, particularly in nerve and brain cell functioning. However, excessive serotonin levels can lead to a rare but potentially serious condition known as serotonin toxicity or serotonin syndrome.

The primary cause of serotonin toxicity is medication, especially drugs used for depression and pain management. Over-the-counter products like St. John’s wort and cough medications containing dextromethorphan (DM) can also contribute to serotonin syndrome. The risk increases when multiple medications affecting serotonin levels are combined or when there are changes in medication.

Symptoms of serotonin toxicity are severe and include tremors, agitation, dilated pupils, increased heart rate, diarrhea, high fever, blood pressure fluctuations, heavy sweating, muscle spasms or rigidity, confusion, and hallucinations. Without prompt treatment, symptoms can worsen, leading to coma or death. If you suspect serotonin toxicity or experience concerning medication-related effects, it’s crucial to consult a doctor or pharmacist immediately. Stopping medication abruptly without professional guidance is not recommended. In severe cases, such as high fever, muscle spasms, or confusion, seeking emergency medical attention is vital.

To prevent serotonin toxicity, patients should:

Inform their doctor and pharmacist about all medications, including over-the-counter and natural health products. Avoid self-adjusting medication doses; consult with a healthcare professional first. Check with a doctor or pharmacist before using natural health products or over-the-counter medications. Inform healthcare providers about recreational drug use.